Tridax procumbens Linn. (Family: Asteraceae) is being used in traditional medicine for the prevention and treatment of ulcer. In our previous work on same plant material Tridax procumbens Linn for evaluation of anti-ulcer activity by using histopathology and ulcer index on mice and rats it is revealed that methanol extract 100 mg/kg was found to be effective in protection of ulcer as compare to petroleum ether extract. Therefore in present research work our aim was to validate protective effect of methanol extract of Tridax Procumbens Linn potential in ulcerative colitis in albino rats by using myeloperoxidase activity. In the present study methanol extract 100 mg/kg of Tridax procumbens Linn was validated for ulcer protection activity using myeloperoxidase activity in albino rats. The results of present investigation showed that the myeloperoxidase activity of methanol extract 100 mg/kg was 2.74 U/g which was near about 50% lower than Experimental Control which is 4.74 U/g. standard drug prednisolone 5 mg/kg which shows 0.85 U/g. From the myeloperoxidase activity study it can be concluded that the methanolic extract (100 mg/kg) of whole plant of Tridax procumbens Linn shows ulcer prevention and protection activity and may be useful for prevention of ulcerative colitis.
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